Dephosphorylation of branched-chain α-keto acid dehydrogenase E1α (BCKDHA) promotes branched-chain amino acid catabolism and renders cancer cells resistant to X-rays by mitigating DNA damage.

Biochemical and biophysical research communications2025Bo T, Osaki T, Fujii J

Study designOther primary literature

SubjectHuman

Abstract

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MeSH

3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide)Amino Acids, Branched-ChainCell Line, TumorCell SurvivalDNA DamageHumansPhosphorylationRadiation ToleranceX-Rays

DOI 10.1016/j.bbrc.2024.151154

PMID 39672007

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