CPT1A loss disrupts BCAA metabolism to confer therapeutic vulnerability in TP53-mutated liver cancer.

Cancer letters2024Liu Y, Wang F, Yan G, et al.

Study designOther primary literature

SubjectHuman & animal

Abstract

cc by 以外（cc by-nc / cc by-nc-nd / NONE 等）は抄録を再掲しない。DOI/PMID へのリンクのみ表示する。

MeSH

Acetyl Coenzyme AAmino Acids, Branched-ChainAnimalsCarcinoma, HepatocellularCarnitine O-PalmitoyltransferaseCell Line, TumorGene Expression Regulation, NeoplasticHumansLipid MetabolismLiver NeoplasmsMaleMiceMutationSignal TransductionTOR Serine-Threonine KinasesTumor Suppressor Protein p53Xenograft Model Antitumor Assays

DOI 10.1016/j.canlet.2024.217006

PMID 38823763

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