ZERO WORLD RESEARCHLiterature database on amino acids & organic acids

Structure-based design and synthesis of N(omega)-nitro-L-arginine-containing peptidomimetics as selective inhibitors of neuronal nitric oxide synthase. Displacement of the heme structural water.

Journal of medicinal chemistry2007Seo J, Igarashi J, Li H, et al.
Study designOther primary literature
SubjectUnknown

Abstract

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MeSH

BiomimeticsCrystallography, X-RayDrug DesignHemeHydrogen BondingModels, MolecularMolecular StructureNitric Oxide Synthase Type INitroargininePeptidesProtein IsoformsStereoisomerismStructure-Activity RelationshipThermodynamicsWater

DOI 10.1021/jm061305c

PMID 17425297

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