Inhibition of the gut enzyme intestinal alkaline phosphatase may explain how aspartame promotes glucose intolerance and obesity in mice.
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme2017Gul SS, Hamilton AR, Munoz AR, et al.
Study designOther primary literature
SubjectAnimal
Abstract
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MeSH
Alkaline PhosphataseAnimalsAspartameBiomarkersBiotransformationBlood GlucoseDiet, High-FatEnzyme InhibitorsGlucose IntoleranceInsulin ResistanceIntestinal MucosaIntestine, SmallMaleMetabolic SyndromeMice, Inbred C57BLNon-Nutritive SweetenersObesityPhenylalanineTumor Necrosis Factor-alphaWeight Gain