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Caffeine potentiates the dependence induced by central nervous system depressants contained in over-the-counter medications in mice.

The Journal of toxicological sciences2026Yonemura-Hirata A, Kaizaki-Mitsumoto A, Numazawa S
Study designOther primary literature
SubjectAnimal

Abstract

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MeSH

AnimalsBenzazepinesCaffeineCentral Nervous System StimulantsDextromethorphanDiphenhydramineDose-Response Relationship, DrugDrug InteractionsDrug SynergismMaleMiceNonprescription DrugsSubstance-Related Disorders

DOI 10.2131/jts.51.131

PMID 41621858

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