Development of a generic physiologically based pharmacokinetic model to predict clinical pharmacokinetics and assess drug-drug interaction risks for valine-citrulline-monomethyl auristatin E-based antibody-drug conjugates.

Drug metabolism and disposition: the biological fate of chemicals2026Shen C, Wang R, Yan J, et al.

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MeSH

ATP Binding Cassette Transporter, Subfamily B, Member 1CitrullineCytochrome P-450 CYP3A InducersDrug InteractionsHumansImmunoconjugatesModels, BiologicalOligopeptides

DOI 10.1016/j.dmd.2026.100289

PMID 42066734

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