Integration of UHPLC-MS and mass spectrometry imaging techniques revealed the protective mechanism of Gushudan in postmenopausal osteoporosis rats via branched-chain amino acid metabolism based on the 'kidney-bone' axis.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences2025Ren M, Wang Y, Yuan Y, et al.

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MeSH

Amino Acids, Branched-ChainAnimalsBone and BonesChromatography, High Pressure LiquidDrugs, Chinese HerbalFemaleKidneyMetabolomeMetabolomicsOsteoporosis, PostmenopausalRatsRats, Sprague-DawleyTandem Mass Spectrometry

DOI 10.1016/j.jchromb.2025.124540

PMID 40023006

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