N-hydroxylation of the antiprotozoal drug pentamidine catalyzed by rabbit liver cytochrome P-450 2C3 or human liver microsomes, microsomal retroreduction, and further oxidative transformation of the formed amidoximes. Possible relationship to the biological oxidation of arginine to NG-hydroxyarginine, citrulline, and nitric oxide.

Drug metabolism and disposition: the biological fate of chemicals1994Clement B, Jung F

研究デザインその他の原著論文

対象ヒト・動物併記

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MeSH

AnimalsArginineBiotransformationCatalysisCitrullineCytochrome P-450 Enzyme SystemHumansHydroxylationIsoenzymesLiverMicrosomes, LiverNitric OxideOxidation-ReductionOximesPentamidineRabbits

DOI 10.1016/s0090-9556(25)08402-8

PMID 8070328

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