Caffeine's neuroprotection against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity shows no tolerance to chronic caffeine administration in mice.
Neuroscience letters2002Xu K, Xu YH, Chen JF, et al.
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MeSH
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAnimalsBinding SitesCaffeineDopamineDopamine AgentsDopamine Plasma Membrane Transport ProteinsDopamine Uptake InhibitorsDrug Administration ScheduleDrug ToleranceMaleMazindolMembrane GlycoproteinsMembrane Transport ProteinsMiceMice, Inbred C57BLMotor ActivityNeostriatumNerve Tissue ProteinsNeuronsNeuroprotective AgentsNeurotoxinsParkinsonian DisordersPurinergic P1 Receptor AntagonistsRadioligand AssayReceptor, Adenosine A2AReceptors, Purinergic P1Tritium
DOI 10.1016/s0304-3940(02)00069-1
PMID 11958832
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