BCAT2-mediated BCAA catabolism is critical for development of pancreatic ductal adenocarcinoma.
Nature cell biology2020Li JT, Yin M, Wang D, et al.
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MeSH
AdenocarcinomaAdultAmino Acids, Branched-ChainAnimalsCarcinogenesisCarcinoma, Pancreatic DuctalCell Line, TumorDisease ProgressionFemaleGene Expression Regulation, NeoplasticHeterograftsHumansIsoenzymesKeto AcidsMaleMiceMice, TransgenicMiddle AgedMinor Histocompatibility AntigensOrganoidsPancreatic DuctsPancreatic NeoplasmsPregnancy ProteinsProto-Oncogene Proteins p21(ras)RibonucleoproteinsSS-A AntigenSignal TransductionSyk KinaseTransaminases
DOI 10.1038/s41556-019-0455-6
PMID 32029896
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