Phosphodiesterase-5A (PDE5A) is localized to the endothelial caveolae and modulates NOS3 activity.
Cardiovascular research2011Gebska MA, Stevenson BK, Hemnes AR, et al.
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MeSH
AnimalsAortaCattleCaveolaeCells, CulturedCoronary VesselsCyclic GMP-Dependent Protein Kinase Type ICyclic GMP-Dependent Protein KinasesCyclic Nucleotide Phosphodiesterases, Type 5Endothelial CellsHumansHypertension, PulmonaryMembrane MicrodomainsMiceNitric Oxide Synthase Type IIIPulmonary ArterySignal TransductionUmbilical VeinsVasodilation