Cytotoxicity of human recombinant arginase I (Co)-PEG5000 in the presence of supplemental L-citrulline is dependent on decreased argininosuccinate synthetase expression in human cells.

Anti-cancer drugs2012Agrawal V, Woo JH, Mauldin JP, et al.

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MeSH

Antineoplastic AgentsArginaseArginineArgininosuccinate SynthaseCell Line, TumorCell ProliferationCitrullineCulture MediaDrug Screening Assays, AntitumorEpithelial CellsHumansMaleOrnithine CarbamoyltransferasePolyethylene GlycolsProtein Synthesis InhibitorsRecombinant Proteins

DOI 10.1097/cad.0b013e32834ae42b

PMID 21955999

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