Anti-arthritis effects of (E)-2,4-bis(p-hydroxyphenyl)-2-butenal are mediated by inhibition of the STAT3 pathway.
British journal of pharmacology2014Ban JO, Kim DH, Lee HP, et al.
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MeSH
AdultAgedAldehydesAnimalsAnti-Inflammatory AgentsArthritis, ExperimentalCell LineCell SurvivalCells, CulturedCyclooxygenase 2CytokinesDinoprostoneFemaleFoot JointsHumansI-kappa B KinaseLipopolysaccharidesMaleMiceMice, Inbred DBAMiddle AgedNF-kappa BNitric OxideNitric Oxide Synthase Type IIPhenolsRNA, MessengerReactive Oxygen SpeciesSTAT3 Transcription FactorSignal TransductionSynovial Membrane