Interleukin-12 (IL-12) enhancement of the cellular immune response against human immunodeficiency virus type 1 env antigen in a DNA prime/vaccinia virus boost vaccine regimen is time and dose dependent: suppressive effects of IL-12 boost are mediated by nitric oxide.

Journal of virology2000Gherardi MM, Ramírez JC, Esteban M

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対象ヒト・動物併記

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MeSH

AnimalsCD8-Positive T-LymphocytesCytokinesDose-Response Relationship, ImmunologicGene Products, envGenetic VectorsHIV-1HumansImmune ToleranceImmunity, CellularImmunization, SecondaryInterleukin-12MiceMice, Inbred BALB CNitric OxideSpleenTh1 CellsTh2 CellsTime FactorsVaccines, DNAVaccinia virus

DOI 10.1128/jvi.74.14.6278-6286.2000

PMID 10864637

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