Molecular Basis of Valine-Citrulline-PABC Linker Instability in Site-Specific ADCs and Its Mitigation by Linker Design.
Molecular cancer therapeutics2016Dorywalska M, Dushin R, Moine L, et al.
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MeSH
AnimalsAntibodies, MonoclonalAntineoplastic AgentsBiomarkersCarbamatesCarboxylesteraseCitrullineDrug DesignDrug StabilityHumansImmunoconjugatesMiceMice, KnockoutModels, MolecularMolecular ConformationMolecular StructureProtein BindingStructure-Activity RelationshipValine
DOI 10.1158/1535-7163.mct-15-1004
PMID 26944918
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