Coffee and caffeine potentiate the antiamyloidogenic activity of melatonin via inhibition of Aβ oligomerization and modulation of the Tau-mediated pathway in N2a/APP cells.

Drug design, development and therapy2015Zhang LF, Zhou ZW, Wang ZH, et al.

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MeSH

Amyloid beta-PeptidesAnimalsCaffeineCell SurvivalCoffeeDose-Response Relationship, DrugMelatoninMiceMolecular Docking SimulationProtein Aggregation, PathologicalProtein MultimerizationStructure-Activity RelationshipTumor Cells, Culturedtau Proteins

DOI 10.2147/dddt.s71106

PMID 25565776

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