Acupuncture Therapy plus Hyaluronic Acid Injection for Knee Osteoarthritis: A Meta-Analysis of Randomized Controlled Trials.

膝変形性関節症に対する鍼治療とヒアルロン酸注射の併用：ランダム化比較試験のメタ分析（機械翻訳の邦題）

Evidence-based complementary and alternative medicine : eCAM2020Zheng Y, Duan X, Qi S, et al.

研究デザインレビュー

対象未確定

記録の確認項目

研究デザイン: レビュー
対象: 未確定
出版年: 2020
出典: doi.org
抄録の表示: 表示あり
出版状態: 有効な記録
状態確認日: 2026/08/17
収集日: 2026/08/04
鮮度: 確認期限内
確認段階: 自動処理
記録状態: 公開

日本語要約（機械生成）

本研究は、膝変形性関節症患者に対する鍼治療とヒアルロン酸注射の併用療法が、ヒアルロン酸注射単独療法と比較して有効かどうかを検討するため、メタ分析を行った。対象は関連するランダム化比較試験10件、参加者998名。解析の結果、併用療法は単独療法と比較して、視覚アナログ尺度（VAS）による疼痛を有意に軽減し、Lysholm膝スコア（LKSS）による膝機能と有効率（ER）を有意に改善した。具体的には、LKSSの平均差は8.09（95%信頼区間7.02〜9.16）、ERの相対リスクは1.23（95%信頼区間1.15〜1.31）であった。しかし、含まれた研究の質が低く、規模が小さく、バイアスのリスクが高いことから、結果の確認には大規模で質の高いランダム化比較試験が必要であると結論づけた。

この要約は公開抄録のみを根拠にAIが機械的に生成したものです。正確な内容は原文を確認してください。

抄録

Objective: This meta-analysis aimed to investigate the effectiveness of acupuncture therapy plus hyaluronic acid injection versus hyaluronic acid injection alone for patients with knee osteoarthritis.Methods: Relevant randomized controlled trials that compared the combined effect of acupuncture therapy and hyaluronic acid injection with hyaluronic acid injection alone for knee osteoarthritis patients were included. 10 studies were included in this meta-analysis, and the relative risk (RR) and weight mean difference (MD) with 95% CI for the Lysholm knee score (LKSS), visual analogue scale (VAS), and effective rate (ER) were evaluated by using RevMan 5.3 software. Besides, the bias assessment of the included studies was evaluated using the Cochrane risk of bias tool, and the GRADE (Grading of Recommendations, Assessment Development, and Evaluation) system was applied to assess the overall quality of the evidence.Results: A total of 10 studies involving 998 participants were included in this study. Compared to hyaluronic acid injection alone, the combined therapy significantly reduced pain on the visual analogue scale (VAS) and improved the ER and knee function on the Lysholm knee score (LKSS). Of these, the pooled LKSS (MD = 8.09, 95% CI = [7.02, 9.16], p < 0.00001, 7 studies) and ER (RR = 1.23, 95% CI 1.15 to 1.31, p < 0.00001, 7 studies) and ER (RR = 1.23, 95% CI 1.15 to 1.31, p < 0.00001, 7 studies) and ER (RR = 1.23, 95% CI 1.15 to 1.31.Conclusion: Current evidence suggests that acupuncture therapy combined with hyaluronic acid injection is more effective in alleviating pain, improving the ER and knee function compared with hyaluronic acid injection alone. However, considering the low quality, small size, and high risk of the studies identified in this meta-analysis, more higher methodological quality, rigorously designed randomized controlled trials with large sample sizes are needed to confirm the results.

DOI 10.1155/2020/4034105

PMID 32015753

原文・出典を見る →