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Structure-based design and synthesis of N(omega)-nitro-L-arginine-containing peptidomimetics as selective inhibitors of neuronal nitric oxide synthase. Displacement of the heme structural water.

Journal of medicinal chemistry2007Seo J, Igarashi J, Li H, et al.
Study designOther primary literature
SubjectUnknown

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Study design
Other primary literature
Subject
Unknown
Publication year
2007
Source
doi.org
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Active
Status checked
17 Aug 2026
Collected
3 Aug 2026
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Current
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Automated
Record status
Published

Abstract

cc by 以外(cc by-nc / cc by-nc-nd / NONE 等)は抄録を再掲しない。DOI/PMID へのリンクのみ表示する。

MeSH

BiomimeticsCrystallography, X-RayDrug DesignHemeHydrogen BondingModels, MolecularMolecular StructureNitric Oxide Synthase Type INitroargininePeptidesProtein IsoformsStereoisomerismStructure-Activity RelationshipThermodynamicsWater

DOI 10.1021/jm061305c

PMID 17425297

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