Antidepressant action of ketamine via mTOR is mediated by inhibition of nitrergic Rheb degradation.

Molecular psychiatry2016Harraz MM, Tyagi R, Cortés P, et al.

Study designOther primary literature

SubjectHuman & animal

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Study design: Other primary literature
Subject: Human & animal
Publication year: 2016
Source: doi.org
Abstract display: Not reproduced here
Publication status: Active
Status checked: 17 Aug 2026
Collected: 3 Aug 2026
Freshness: Current
Review stage: Automated
Record status: Published

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Abstract

cc by 以外（cc by-nc / cc by-nc-nd / NONE 等）は抄録を再掲しない。DOI/PMID へのリンクのみ表示する。

MeSH

AnimalsAntidepressive AgentsCells, CulturedCerebral CortexCysteineDepressionDisease Models, AnimalEmbryo, MammalianExploratory BehaviorFemaleGene Expression RegulationHEK293 CellsHumansKetamineMaleMice, Inbred C57BLMice, KnockoutMonomeric GTP-Binding ProteinsN-MethylaspartateNeuronsNeuropeptidesNitric OxideNitric Oxide Synthase Type INitric Oxide Synthase Type IIPregnancyProteolysisRas Homolog Enriched in Brain ProteinS-NitrosothiolsSignal TransductionSwimmingTOR Serine-Threonine KinasesTime Factors

DOI 10.1038/mp.2015.211

PMID 26782056

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