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Five New Limonoids from Peels of Satsuma Orange (Citrus reticulata).

Molecules (Basel, Switzerland)2017Kikuchi T, Ueno Y, Hamada Y, et al.
Study designOther primary literature
SubjectAnimal

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Study design
Other primary literature
Subject
Animal
Publication year
2017
Source
doi.org
Abstract display
Shown here
Publication status
Active
Status checked
17 Aug 2026
Collected
3 Aug 2026
Freshness
Current
Review stage
Automated
Record status
Published

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Abstract

Five new: 21,23-dihydro-21-hydroxy-23-oxonomilin (1), 21,23-dihydro-23-methoxy-21-oxonomilin (2), 21,23-dihydro-21-hydroxy-23-oxonomilinic acid methyl ester (3), 21,23-dihydro-23-methoxy-21-oxolimonin (4), and 21,23-dihydro-21-oxolimonin (5), and seven known limonoids were isolated from peels of satsuma orange (Citrus reticulata). The isolated compounds were evaluated for their inhibitory effects on macrophage activation by an inhibitory assay of nitric oxide (NO) production. Among them, compound (2) exhibited NO inhibitory activity without cytotoxicity.

MeSH

AnimalsCell SurvivalCitrusFruitLimoninsMacrophage ActivationMagnetic Resonance SpectroscopyMiceMolecular StructureNitric OxideRAW 264.7 CellsWaste Products

DOI 10.3390/molecules22060907

PMID 28561764

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