ZERO WORLD RESEARCHLiterature database on amino acids & organic acids
NO Pathway

Bioactive Phenolic and Isocoumarin Glycosides from the Stems of Homalium paniculiflorum.

Molecules (Basel, Switzerland)2018Wu SY, Fu YH, Zhou Q, et al.
Study designOther primary literature
SubjectHuman & animal

Record checks

Study design
Other primary literature
Subject
Human & animal
Publication year
2018
Source
doi.org
Abstract display
Shown here
Publication status
Active
Status checked
17 Aug 2026
Collected
3 Aug 2026
Freshness
Current
Review stage
Automated
Record status
Published

How to read this record →

Abstract

Two new phenolic glycosides (1 and 2) and two new isocoumarin glycosides (3 and 4), along with 14 known compounds (5-18), were isolated from the stems of Homalium paniculiflorum. Their structures were established on the basis of extensive spectroscopic analyses and chemical methods. All new compounds were evaluated for their anti-inflammatory activities via examining the inhibitory activity on nitric oxide (NO) production induced by lipopolysaccharide (LPS) in mouse macrophage RAW 264.7 cells in vitro. Compounds 1 and 4 exhibited inhibitory activities with IC50 values of 30.23 ± 1.23 μM and 19.36 ± 0.19 μM, respectively.

MeSH

AnimalsGlycosidesHumansInflammationIsocoumarinsLipopolysaccharidesMiceNitric OxidePhenolPlant StemsRAW 264.7 CellsSalicaceae

DOI 10.3390/molecules23020472

PMID 29470386

View source →