Cartilage targeting hydrogel nanoplatform degrades BRD4 to alleviate osteoarthritis via Nav1.7 axis.

Nature communications2026Zhao Q, Xu T, Du Z, et al.

Study designOther primary literature

SubjectHuman & animal

Abstract

cc by 以外（cc by-nc / cc by-nc-nd / NONE 等）は抄録を再掲しない。DOI/PMID へのリンクのみ表示する。

MeSH

AnimalsBromodomain Containing ProteinsCartilage, ArticularCell Cycle ProteinsChondrocytesDisease Models, AnimalHumansHydrogelsMaleMiceMice, Inbred C57BLMitochondriaNAV1.7 Voltage-Gated Sodium ChannelNanoparticlesNuclear ProteinsOsteoarthritisProteolysisProteolysis Targeting ChimeraTranscription Factors

DOI 10.1038/s41467-026-71246-w

PMID 41904167

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