Cartilage targeting hydrogel nanoplatform degrades BRD4 to alleviate osteoarthritis via Nav1.7 axis.
Nature communications2026Zhao Q, Xu T, Du Z, et al.
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MeSH
AnimalsBromodomain Containing ProteinsCartilage, ArticularCell Cycle ProteinsChondrocytesDisease Models, AnimalHumansHydrogelsMaleMiceMice, Inbred C57BLMitochondriaNAV1.7 Voltage-Gated Sodium ChannelNanoparticlesNuclear ProteinsOsteoarthritisProteolysisProteolysis Targeting ChimeraTranscription Factors
DOI 10.1038/s41467-026-71246-w
PMID 41904167
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