Cytotoxicity of activated rat macrophages against syngeneic islet cells is arginine-dependent, correlates with citrulline and nitrite concentrations and is identical to lysis by the nitric oxide donor nitroprusside.

Diabetologia1993Kröncke KD, Rodriguez ML, Kolb H, et al.

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MeSH

1-Methyl-3-isobutylxanthineAnimalsArginineCells, CulturedCitrullineCyclic GMPFemaleIslets of LangerhansKineticsMacrophage ActivationMacrophagesMaleNitric OxideNitritesNitroprussideRatsRats, WistarThionucleotidesomega-N-Methylarginine

DOI 10.1007/bf00399088

PMID 7679656

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