Long-term nitric oxide deficiency causes muscarinic supersensitivity and reduces beta(3)-adrenoceptor-mediated relaxation, causing rat detrusor overactivity.
British journal of pharmacology2008Mónica FZ, Bricola AA, Báu FR, et al.
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MeSH
Adrenergic beta-3 Receptor AgonistsAdrenergic beta-AgonistsAnimalsCarbacholInositol PhosphatesMaleMuscarinic AgonistsMuscle ContractionMuscle, SmoothNG-Nitroarginine Methyl EsterNitric OxideNitric Oxide SynthaseRatsRats, WistarReceptors, Adrenergic, beta-3Receptors, MuscarinicUrinary BladderUrinary Bladder, Overactive