Development of a generic physiologically based pharmacokinetic model to predict clinical pharmacokinetics and assess drug-drug interaction risks for valine-citrulline-monomethyl auristatin E-based antibody-drug conjugates.その他の原著論文ヒト有効な記録Drug metabolism and disposition: the biological fate of chemicals2026
Shen C, Wang R, Yan J, et al.
L-Citrulline in Maternal-Fetal and Neonatal Health: Metabolic Mechanisms and Emerging Therapeutic Applications.レビューヒト有効な記録Nutrients2026
Collins-Smith A, Jain S, Jain S
L-Arginine and Nitric Oxide in Vascular Regulation-Experimental Findings in the Context of Blood Donation.レビューヒト・動物 併記有効な記録Nutrients2025
Kurhaluk N, Tkaczenko H
Divergent roles of red cell arginase in humans and mice: RBC Arg1 KO mice show preserved systemic l-arginine bioavailability and infarct size in vivo.その他の原著論文ヒト・動物 併記有効な記録Redox biology2025
Heuser SK, Li J, Li Z, et al.
The Discovery of Selective Protein Arginine Methyltransferase 5 Inhibitors in the Management of β-Thalassemia through Computational Methods.その他の原著論文ヒト有効な記録Molecules (Basel, Switzerland)2024
Pokharel B, Ravikumar Y, Rathinavel L, et al.
Low global arginine bioavailability: a common phenomenon in pulmonary hypertension.その他の原著論文ヒト有効な記録American journal of physiology. Lung cellular and molecular physiology2024
Hatabah D, De Marco T, McGlothlin DP, et al.
Lower Arginine Bioavailability, Increased FeNO Levels, and Airway Resistance on Impulse Oscillometry Are Characteristics of Asthma in Children and Young Adults with Sickle Cell Disease.その他の原著論文ヒト有効な記録Medicina (Kaunas, Lithuania)2024
Ozhan AK, Arikoglu T, Er M, et al.
Improving the Bioavailability and Efficacy of Coenzyme Q10 on Alzheimer's Disease Through the Arginine Based Proniosomes.その他の原著論文ヒト・動物 併記有効な記録Journal of pharmaceutical sciences2023
Ergin AD, Üner B, Balcı Ş, et al.
Barriers to the Intestinal Absorption of Four Insulin-Loaded Arginine-Rich Nanoparticles in Human and Rat.その他の原著論文ヒト・動物 併記有効な記録ACS nano2022
Lundquist P, Khodus G, Niu Z, et al.
Design, Synthesis and Biological Evaluation of Novel and Potent Protein Arginine Methyltransferases 5 Inhibitors for Cancer Therapy.その他の原著論文ヒト有効な記録Molecules (Basel, Switzerland)2022
Tang Y, Huang S, Chen X, et al.
Excellent Multiphoton Excitation Fluorescence with Large Multiphoton Absorption Cross Sections of Arginine-Modified Gold Nanoclusters for Bioimaging.その他の原著論文ヒト有効な記録ACS applied materials & interfaces2022
Wei Z, Pan Y, Hou G, et al.
Effect of food sources of nitrate, polyphenols, L-arginine and L-citrulline on endurance exercise performance: a systematic review and meta-analysis of randomised controlled trials.メタ分析ヒト有効な記録Journal of the International Society of Sports Nutrition2021
d'Unienville NMA, Blake HT, Coates AM, et al.
Acute L-Citrulline Supplementation Increases Nitric Oxide Bioavailability but Not Inspiratory Muscle Oxygenation and Respiratory Performance.その他の原著論文ヒト有効な記録Nutrients2021
Theodorou AA, Zinelis PT, Malliou VJ, et al.
l-Arginine/l-lysine functionalized chitosan-casein core-shell and pH-responsive nanoparticles: fabrication, characterization and bioavailability enhancement of hydrophobic and hydrophilic bioactive compounds.その他の原著論文ヒト有効な記録Food & function2020
Du Z
, Liu J
, Zhang H
, et al.
Altered Bioavailability of Nitric Oxide and L-Arginine Is a Key Determinant of Endothelial Dysfunction in Preeclampsia.その他の原著論文ヒト有効な記録BioMed research international2020
Tashie W, Fondjo LA, Owiredu WKBA, et al.
Enhanced Fluoride Bioavailability with Incorporation of Arginine in Child Dentifrices.その他の原著論文ヒト有効な記録The Journal of clinical pediatric dentistry2020
Bijle MN, Tsoi J, Ekambaram M, et al.
Lack of relationship between fasting plasma citrulline and glucose absorption: do not underestimate the role of the failing kidney!その他の原著論文ヒト有効な記録Critical care (London, England)2019
Honore PM, De Bels D, Gallerani A, et al.
Aspergillus nidulans thermostable arginine deiminase-Dextran conjugates with enhanced molecular stability, proteolytic resistance, pharmacokinetic properties and anticancer activity.その他の原著論文ヒト・動物 併記有効な記録Enzyme and microbial technology2019
El-Sayed ASA, Shindia AA, Zeid AAA, et al.
Metabolites of the Nitric Oxide (NO) Pathway Are Altered and Indicative of Reduced NO and Arginine Bioavailability in Patients with Cardiometabolic Diseases Complicated with Chronic Wounds of Lower Extremities: Targeted Metabolomics Approach (LC-MS/MS).その他の原著論文ヒト有効な記録Oxidative medicine and cellular longevity2019
Krzystek-Korpacka M, Wiśniewski J, Fleszar MG, et al.
Global arginine bioavailability ratio is decreased in patients with major depressive disorder.その他の原著論文ヒト有効な記録Journal of affective disorders2018
Ali-Sisto T, Tolmunen T, Viinamäki H, et al.
Drastic decrease of global l-arginine bioavailability during orthotopic liver transplantation: A matter of ATP deficiency of the graft?その他の原著論文ヒト有効な記録Nitric oxide : biology and chemistry2018
Tsikas D, Hanff E, Becker T
Arginine bioavailability and endothelin-1 system in the regulation of vascular function of umbilical vein endothelial cells from intrauterine growth restricted newborns.その他の原著論文ヒト有効な記録Nutrition, metabolism, and cardiovascular diseases : NMCD2018
He Q, Liu X, Zhong Y, et al.
Malaria in pregnancy alters l-arginine bioavailability and placental vascular development.その他の原著論文ヒト・動物 併記有効な記録Science translational medicine2018
McDonald CR, Cahill LS, Gamble JL, et al.
Enhanced In Vitro Zinc Bioavailability through Rational Design of a Dual Zinc plus Arginine Dentifrice.その他の原著論文ヒト有効な記録The Journal of clinical dentistry2018
Manus LM, Daep CA, Begum-Gafur R, et al.
Potential of single cationic amino acid molecule "Arginine" for stimulating oral absorption of insulin.その他の原著論文ヒト・動物 併記有効な記録International journal of pharmaceutics2017
Kamei N, Khafagy ES, Hirose J, et al.
GC-MS and GC-MS/MS measurement of ibuprofen in 10-μL aliquots of human plasma and mice serum using [α-methylo-2H3]ibuprofen after ethyl acetate extraction and pentafluorobenzyl bromide derivatization: Discovery of a collision energy-dependent H/D isotope effect and pharmacokinetic application to inhaled ibuprofen-arginine in mice.その他の原著論文ヒト・動物 併記有効な記録Journal of chromatography. B, Analytical technologies in the biomedical and life sciences2017
Tsikas D, Kayacelebi AA, Hanff E, et al.
Small Molecule Inhibitors of Protein Arginine Methyltransferases.レビューヒト・動物 併記有効な記録Expert opinion on investigational drugs2016
Hu H, Qian K, Ho MC, et al.
Global arginine bioavailability, a marker of nitric oxide synthetic capacity, is decreased in PTSD and correlated with symptom severity and markers of inflammation.その他の原著論文ヒト有効な記録Brain, behavior, and immunity2016
Bersani FS, Wolkowitz OM, Lindqvist D, et al.
Nitric Oxide-Dependent Endothelial Dysfunction and Reduced Arginine Bioavailability in Plasmodium vivax Malaria but No Greater Increase in Intravascular Hemolysis in Severe Disease.その他の原著論文ヒト有効な記録The Journal of infectious diseases2016
Barber BE, William T, Grigg MJ, et al.
Pharmacokinetic-Pharmacodynamic Model for the Effect of l-Arginine on Endothelial Function in Patients with Moderately Severe Falciparum Malaria.観察研究ヒト有効な記録Antimicrobial agents and chemotherapy2016
Brussee JM, Yeo TW, Lampah DA, et al.
The effects of linagliptin on endothelial function and global arginine bioavailability ratio in coronary artery disease patients with early diabetes: study protocol for a randomized controlled trial.ランダム化比較試験ヒト有効な記録Trials2016
Tripolt NJ, Aberer F, Riedl R, et al.
Effects of Dietary l-Arginine on Nitric Oxide Bioavailability in Obese Normotensive and Obese Hypertensive Subjects.その他の原著論文ヒト有効な記録Nutrients2016
Giam B, Kuruppu S, Head GA, et al.
Investigation of a potential pharmacokinetic interaction between perindopril arginine and amlodipine when administered as a single perindopril/amlodipine fixed-dose combination tablet in healthy Chinese male volunteers.ランダム化比較試験ヒト有効な記録International journal of clinical pharmacology and therapeutics2016
Zheng X, Liu T, Chen X, et al.
Simultaneous determination of citrulline and arginine in human blood plasma by capillary electrophoresis with ultraviolet absorption detection.その他の原著論文ヒト有効な記録Journal of separation science2014
Forteschi M, Sotgia S, Pintus G, et al.
Oral supplementation with a combination of L-citrulline and L-arginine rapidly increases plasma L-arginine concentration and enhances NO bioavailability.その他の原著論文ヒト・動物 併記有効な記録Biochemical and biophysical research communications2014
Morita M, Hayashi T, Ochiai M, et al.
Diminished global arginine bioavailability as a metabolic defect in chronic systolic heart failure.その他の原著論文ヒト有効な記録Journal of cardiac failure2013
Tang WH, Shrestha K, Wang Z, et al.
Arginine vasopressin-dependent and AVP-independent mechanisms of renal fluid absorption during thirsting despite glucocorticoid-mediated vasopressin suppression.その他の原著論文ヒト有効な記録Clinical endocrinology2013
Ufer F, Diederich S, Pedersen EB, et al.
Multifactorial risk factor intervention in patients with Type 2 diabetes improves arginine bioavailability ratios.その他の原著論文ヒト有効な記録Diabetic medicine : a journal of the British Diabetic Association2012
Tripolt NJ, Meinitzer A, Eder M, et al.
Arginine bioavailability ratios are associated with cardiovascular mortality in patients referred to coronary angiography.その他の原著論文ヒト有効な記録Atherosclerosis2011
Sourij H, Meinitzer A, Pilz S, et al.
Global arginine bioavailability in Tanzanian sickle cell anaemia patients at steady-state: a nested case control study of deaths versus survivors.その他の原著論文ヒト有効な記録British journal of haematology2011
Cox SE, Makani J, Komba AN, et al.
Arginine metabolism and nitric oxide bioavailability in sickle cell disease.その他の原著論文ヒト有効な記録Journal of pediatric hematology/oncology2010
Jain S, Gladwin MT
Dysregulation of L-arginine metabolism and bioavailability associated to free plasma heme.その他の原著論文ヒト有効な記録American journal of physiology. Cell physiology2010
Omodeo-Salè F, Cortelezzi L, Vommaro Z, et al.
Diminished global arginine bioavailability and increased arginine catabolism as metabolic profile of increased cardiovascular risk.その他の原著論文ヒト有効な記録Journal of the American College of Cardiology2009
Tang WH, Wang Z, Cho L, et al.
Increasing plasma glutamine in postoperative patients fed an arginine-rich immune-enhancing diet--a pharmacokinetic randomized controlled study.ランダム化比較試験ヒト有効な記録Critical care medicine2009
Loï C, Zazzo JF, Delpierre E, et al.
Mechanisms and kinetics of citrulline uptake in a model of human intestinal epithelial cells.その他の原著論文ヒト有効な記録Clinical nutrition (Edinburgh, Scotland)2008
Bahri S, Curis E, El Wafi FZ, et al.
Dose-ranging effects of citrulline administration on plasma amino acids and hormonal patterns in healthy subjects: the Citrudose pharmacokinetic study.ランダム化比較試験ヒト有効な記録The British journal of nutrition2008
Moinard C, Nicolis I, Neveux N, et al.
Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism.ランダム化比較試験ヒト有効な記録British journal of clinical pharmacology2008
Schwedhelm E, Maas R, Freese R, et al.
Citrulline blood levels as indicators of residual intestinal absorption in patients with short bowel syndrome.その他の原著論文ヒト有効な記録Annals of nutrition & metabolism2008
Santarpia L, Catanzano F, Ruoppolo M, et al.
Fasting plasma citrulline concentrations do not reflect intestinal absorption capacity.その他の原著論文ヒト有効な記録JPEN. Journal of parenteral and enteral nutrition2008
Peters JH, Mulder CJ, van Bodegraven AA
Poor diagnostic accuracy of a single fasting plasma citrulline concentration to assess intestinal energy absorption capacity.その他の原著論文ヒト有効な記録The American journal of gastroenterology2007
Peters JH, Wierdsma NJ, Teerlink T, et al.
[Serum citrulline: a potential marker for intestinal epithelial mass and absorption capacity in short bowel syndrome patients].その他の原著論文ヒト有効な記録Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery2007
Gong JF, Zhu WM, Li N, et al.
Impaired nitric oxide bioavailability and L-arginine reversible endothelial dysfunction in adults with falciparum malaria.その他の原著論文ヒト・動物 併記有効な記録The Journal of experimental medicine2007
Yeo TW, Lampah DA, Gitawati R, et al.
Impaired flow-mediated dilation with age is not explained by L-arginine bioavailability or endothelial asymmetric dimethylarginine protein expression.その他の原著論文ヒト有効な記録Journal of applied physiology (Bethesda, Md. : 1985)2007
Gates PE, Boucher ML, Silver AE, et al.
Adverse effects of cigarette smoke on NO bioavailability: role of arginine metabolism and oxidative stress.その他の原著論文ヒト・動物 併記有効な記録Hypertension (Dallas, Tex. : 1979)2006
Zhang WZ, Venardos K, Chin-Dusting J, et al.
Serum citrulline is a simple quantitative marker for small intestinal enterocytes mass and absorption function in short bowel patients.その他の原著論文ヒト有効な記録The Journal of surgical research2005
Jianfeng G, Weiming Z, Ning L, et al.
An oral yohimbine/L-arginine combination (NMI 861) for the treatment of male erectile dysfunction: a pharmacokinetic, pharmacodynamic and interaction study with intravenous nitroglycerine in healthy male subjects.ランダム化比較試験ヒト有効な記録British journal of clinical pharmacology2005
Kernohan AF, McIntyre M, Hughes DM, et al.
Diminished L-arginine bioavailability in hypertension.その他の原著論文ヒト・動物 併記有効な記録Clinical science (London, England : 1979)2004
Moss MB, Brunini TM, Soares De Moura R, et al.
Decreased arginine bioavailability and increased serum arginase activity in asthma.その他の原著論文ヒト有効な記録American journal of respiratory and critical care medicine2004
Morris CR, Poljakovic M, Lavrisha L, et al.
L-arginine-induced vasodilation in healthy humans: pharmacokinetic-pharmacodynamic relationship.ランダム化比較試験ヒト有効な記録British journal of clinical pharmacology1998
Bode-Böger SM, Böger RH, Galland A, et al.
Preliminary pharmacokinetic study of ibuprofen enantiomers after administration of a new oral formulation (ibuprofen arginine) to healthy male volunteers.ランダム化比較試験ヒト有効な記録Chirality1997
Fornasini G, Monti N, Brogin G, et al.
Effect of L-arginine on intestinal water and sodium absorption.その他の原著論文ヒト・動物 併記有効な記録Gut1997
Holdsworth CD, Hellier MD
Bioavailability of 1-deamino-8-D-arginine vasopressin with an enzyme inhibitor (aprotinin) from the small intestine in healthy volunteers.その他の原著論文ヒト有効な記録European journal of clinical pharmacology1996
Fjellestad-Paulsen A, d'Agay-Abensour L, Höglund P, et al.
Absolute bioavailability of an aqueous solution of 1-deamino-8-D-arginine vasopressin from different regions of the gastrointestinal tract in man.その他の原著論文ヒト有効な記録European journal of clinical pharmacology1993
d'Agay-Abensour L, Fjellestad-Paulsen A, Höglund P, et al.
Elevated plasma concentration of arginine-vasopressin in renal insufficiency is not caused by nonspecific binding of metabolic breakdown products.その他の原著論文ヒト有効な記録Nephron1991
Bald M, Gross P, Rascher W
Pharmacokinetic study of butyric acid administered in vivo as sodium and arginine butyrate salts.その他の原著論文ヒト・動物 併記有効な記録Clinica chimica acta; international journal of clinical chemistry1989
Daniel P, Brazier M, Cerutti I, et al.
Arginine vasopressin in children with moderately impaired renal function. Plasma concentration and its relationship to urinary clearance.その他の原著論文ヒト有効な記録Contributions to nephrology1988
Bald M, Rascher W, Schärer K
Plasma concentration and urinary excretion of arginine vasopressin in children with moderately impaired renal function.その他の原著論文ヒト有効な記録Child nephrology and urology1988
Bald M, Rascher W, Schärer K
Plasma concentration and urinary excretion of arginine-vasopressin in primary aldosteronism during the fluid deprivation tests.その他の原著論文ヒト有効な記録Experimental and clinical endocrinology1983
Horký K, Sramková J, Widimsky J Jr, et al.
Intestinal absorption in lysinuric protein intolerance: impaired for diamino acids, normal for citrulline.その他の原著論文ヒト有効な記録Gut1980
Rajantie J, Simell O, Perheentupa J
[Absorption and oxidation rate of arginine and malate (author's transl)].その他の原著論文ヒト有効な記録Leber, Magen, Darm1978
Herbetz L, Adrian M, Bongers R, et al.
Jejunal and ileal absorption of dibasic amino acids and an arginine-containing dipeptide in cystinuria.その他の原著論文ヒト有効な記録Gastroenterology1975
Silk DB, Perrett D, Clark ML
Intestinal absorption of an arginine-containing peptide in cystinuria.その他の原著論文ヒト有効な記録Gut1972
Asatoor AM, Harrison BD, Milne MD, et al.
Intestinal absorption of L-arginine and L-lysine in familial protein intolerance.その他の原著論文ヒト有効な記録Annales paediatriae Fenniae1968
Kekomäki M